Investigation of Aspirin Overdose Using Salicylate Assay

Investigation of acetylsalicylic acid Overdose Using Salicylate AssayIntroductionAspirin is the most widely used over-the-counter drug in the world. The honest tablet contains about 325 milligrams of acetylsalicylic. Aspirin is used to relieve cark, reduce inflammation, and tear down fever. Aspirin originally was derived by boiling the scrape of the white willow tree tree. Although the salicin in willow bark has palliative properties, purified salicylic dit was bitter and vexatious when taken oral examinationly. Phenylsalicylate could be produced by modifying Salicylic acid which resulted in better gustatory perception and less irritating outcomes. Felix Hoffman and Arthur Eichengrn first produced the active ingredient in aspirin, acetylsalicylic acid, in 1893. However, Hippocrates wrote about a bitter powder extracted from willow bark that could ease aches and trouble oneselfs and reduce fevers during the fifth century B.C two hundred ml well mixed stomach bailiwicks (Sa mple A)- vaporific Yellowcc ml hydrolysed stomach contents (Sample B)- Purple200 ml piddle (Sample D)- Light Purple200 ml negative control (water)- Transparent Yellow200 ml positive control (400 mg /ml sodium salicylate)- PurpleSolution i and iv which where stomach content and negative control turned Transparent Yellow this instrument, No change, ban test. Solutions ii and v turned purple which means that the test where portative for lavishly aspirin traces.Solution iii turned Light Purple which means that slight trances of aspirin are shown the sample.Salicylic acid is a weak acid, and genuinely little as its ionized in the stomach after oral consumption. Acetylsalicylic acid is poorly soluble in the acidic conditions of the stomach, which erect reversion amalgamation of high doses for 8 to 24 hours.In addition to the change magnitude pH of the small intestine, aspirin is rapidly absorbed due to the amplification surface area, which results in allowing more of the salic ylate to dissolve. However, aspirin is absorbed much more slowly during overdose, and plasma concentrations can continue to rise for up to 24 hours after ingestion.As much as 80% of therapeutic doses of salicylic acid are metabolized in the liver.Renal excretion of salicylic acid becomes ever more important as the metabolic pathways become saturated, because it is extremely responsive to changes in urinary pH. There is a 10 to 20 fold increase in renal clearance when urine pH is increased from 5 to 8. The use of urinary alkalinization utilizes this particular aspect of salicylate elimination.From the deductions that can be from by results and investigations, it shows that aspirin is absorbed via the small intestine, which then transported to the blood serum. Waste harvest is transported to urea and disposed via renal excretion. Therefore more aspirin is toast in the serum, that why forms a precipitate and the urine dose not as much of it is waste product.The acutely toxic dose of aspirin is commonly regard as greater than 150mg per kg of body mass. Moderate toxicity occurs at doses up to 300mg/kg, severe toxicity occurs between 300 to 500mg/kg, and a potentially lethal dose is greater than 500mg/kg. continuing toxicity may arise subsequently to doses of 100mg/kg per solar day for two or more days.Around 3 grams per day in divided doses for rheumatoid arthritis is recommended.Serum salicylate levels may be servicingful in guiding therapeutic decisions regarding dosage. Serum salicylate levels of 150 to 300 mcg/mL are associated with anti-inflammatory response. However, the incidence of toxicity increases with salicylate levels greater than 200 mcg/mL.This patients salicylate concentration level levels where 400 mcg/mL. Therefore I believe this person was overdosing on aspirin.The key objectionable side cause of aspirin are tinnitus, gastrointestinal ulcers and stomach bleeding contestably in higher(prenominal) doses this is due to aspirin irritating the stomach lining. In youngsters, aspirin is no longer used to control flu-like symptoms or the symptoms of other viral illnesses, because of the assay of Reyes syndrome. Another common side effect of aspirin is heart burn, this can occur at low doses.Aspirin was once used as an anti-inflammatory drug as well as a pain killer. This results in the medication working as a block pain. For example, when a person has a headache, it is often the result in restriction in the blood vessels of the brain. Aspirin reduces the swelling and in like manner thins down the blood to help with blood flow through the vessels this help in reducing pain and rule oution of recurring when the painkiller properties of aspirin wear off. Aspirin is also effective in reducing fevers. People who have a level of heart problems and those at risk of heart attacks are often certified by doctors to take daily doses of aspirin as a burden measure.The blood thinning properties of aspirin can save a intent in the event of a heart emergency by part some blood to pass through the body until a curdle or blockage can be treated. Aspirin is also a known anti-coagulant, which means that it helps to keep the blood thin and prevents clotting. Anti-coagulant is used to prevent blood clots forming within the blood vessels this can cause heart attack, snapshot or other circulatory system problems.